Determinants of non-vaccination against pandemic 2009 H1N1 influenza in pregnant women: a prospective cohort study.
Determinants of non-vaccination against pandemic 2009 H1N1 influenza in pregnant women: a prospective cohort study.
Blog Article
BackgroundIn October 2009, the French government organized a national-wide, free of charge vaccination campaign against pandemic H1N1 influenza virus, especially targeting pregnant women, a high risk group for severe illness.The study objective was to evaluate pandemic flu vaccine uptake and factors associated with non-vaccination in a population of pregnant women.Methodology/principal findingsIn a prospective cohort conducted in 3 maternity hospitals in Paris, 882 pregnant women were randomly included between October 12, 2009 and February 3, 2010, with the aim to study characteristics of pandemic influenza during pregnancy.At GOLD X GEL PACK inclusion, socio-demographic, medical, obstetrical factors and those associated with a higher risk of flu exposition and disease-spreading were systematically collected.
Pandemic flu vaccine uptake was checked until delivery.555 (62.9%) women did not get vaccinated.Determinants associated with non-vaccination in a multivariate logistic regression were: geographic origin (Sub-Saharan African origin, adjusted Odd Ratio aOR = 5.
4[2.3-12.7], North African origin, aOR = 2.5[1.
3-4.7] and Asian origin, aOR = 2.1[1.7-2.
6] compared to French and European origin) and socio-professional categories (farmers, craftsmen and tradesmen, aOR = 2.3[2.0-2.6], intermediate professionals, aOR = 1.
3[1.0-1.6], employees and manual workers, aOR = 2.5[1.
4-4.4] compared to managers and intellectual professionals).The probability of not receiving pandemic flu vaccine was lower among women vaccinated against seasonal flu in the previous 5 years (aOR = 0.6[0.
4-0.8]) and among those who stopped smoking before or early during pregnancy (aOR = 0.6[0.4-0.
8]).Number of children less than 18 years old living at home, work in contact with children or in healthcare area, or professional contact with the public, were not associated with a higher vaccine uptake.Conclusions/significanceIn this cohort of pregnant women, vaccine coverage PEPPERMINT against pandemic 2009 A/H1N1 flu was low, particularly in immigrant women and those having a low socio-economic status.To improve its effectiveness, future vaccination campaign for pregnant women should be more specifically tailored for these populations.